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Rho GTPases, a family of small GTPases, have recently been found to be involved in the formation of cell polarity and the front. Other PAK homologues may be involved in the formation of cell polarity and the front. PAK stimulates the polymerization of actin filaments. Cloning of p21-activated kinase (PAK), one of the downstream effectors, demonstrated that there are at least two different signaling pathways downstream of Ras and Cdc42 in Dictyostelium. Ras and Cdc42 act through different downstream effectors. While Cdc42 is involved in cell polarity and front formation, Ras has little or no role in these processes. In order to crack software, .Role of Rho family members in cell polarity and front formation in Dictyostelium.Ĭell polarity and front formation have been studied most extensively in Dictyostelium discoideum, and Ras and Cdc42 GTPases, which are involved in cell polarity in many other eukaryotic cells, play crucial roles in morphogenesis of Dictyostelium.
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